SCHEMBL24754191

SCHEMBL24754191

Nc1cccc2c1ccc1onc(C3CCC(=O)NC3=O)c12

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 0.53
DDB1 Q16531 18/20 0.53
BRD4 O60885 1/20 0.37
TNF P01375 2/20 0.37
IL1B P01584 2/20 0.37
IKZF3 Q9UKT9 2/20 0.37
TBXA2R P21731 1/20 0.37
IKZF1 Q13422 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23640469 0.83 DDB1 (0.59) CRBNDDB1
SCHEMBL24302284 0.83 DDB1 (0.59) CRBNDDB1
SCHEMBL23640033 0.83 DDB1 (0.59) CRBNDDB1
SCHEMBL23640399 0.81 DDB1 (0.52) CRBNDDB1IKZF3
SCHEMBL23639962 0.81 DDB1 (0.52) CRBNDDB1IKZF3
SCHEMBL23639961 0.81 DDB1 (0.52) CRBNDDB1IKZF3
SCHEMBL29324611 0.80 CRBN (0.58) CRBNDDB1BRD4TNFIL1B
SCHEMBL24303401 0.79 DDB1 (0.45) CRBNDDB1
SCHEMBL23640252 0.79 DDB1 (0.49) CRBNDDB1TNFIL1BIKZF3
SCHEMBL27064793 0.79 CRBN (0.46) CRBNDDB1BRD4TNFIL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400499-A1 GLUTARIMIDE COMPOUND AND USE THEREOF Medshine Discovery Inc. (CN) 2024-07-17 EP disclosed
WO-2022262782-A1 GLUTARIMIDE-SUBSTITUTED ISOXAZOLE FUSED RING COMPOUND, AND APPLICATION THEREOF 南京明德新药研发有限公司 2022-12-22 WO disclosed