Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1689403 | 0.85 | POLB (0.42) | ALDH1A1POLBKDM4EHSD17B10 | |
| SCHEMBL29655180 | 0.82 | ALDH1A1 (0.47) | ALDH1A1POLBKDM4EHSD17B10GAA | |
| SCHEMBL1689399 | 0.82 | ALDH1A1 (0.47) | ALDH1A1POLBKDM4EHSD17B10GAA | |
| SCHEMBL10091946 | 0.76 | ALDH1A1 (0.47) | ALDH1A1POLBKDM4EHSD17B10GAA | |
| SCHEMBL98965 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14003000 | 0.74 | ALDH1A1 (0.42) | ALDH1A1POLBKDM4EHSD17B10GAA | |
| SCHEMBL2272050 | 0.73 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL13302911 | 0.70 | POLB (0.45) | ALDH1A1POLBKDM4EHSD17B10 | |
| SCHEMBL30408659 | 0.70 | POLB (0.45) | ALDH1A1POLBKDM4EHSD17B10 | |
| SCHEMBL28023416 | 0.70 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2824098-B1 | Method for the preparation of 4-[3-(4-cyclopropanecarbonyl- piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one | KUDOS PHARM LTD (GB) | 2016-06-22 | — | — | EP | claimed |
| EP-2374800-A2 | Methods for the preparation of 4-[3-(4-cyclopropanecarbonyl- piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one | Kudos Pharmaceuticals Limited (GB) | 2011-10-12 | — | — | EP | claimed |
| EP-2374800-A2 | Methods for the preparation of 4-[3-(4-cyclopropanecarbonyl- piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one | Kudos Pharmaceuticals Limited (GB) | 2011-10-12 | — | — | EP | disclosed |