Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 3/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30107048 | 1.00 | NR1H2 (0.41) | NR1H2AKR1C3AKR1C2ELANEKLKB1 | |
| SCHEMBL24758199 | 0.91 | AKR1C3 (0.47) | AKR1C3AKR1C2KLKB1CARM1IRAK4 | |
| SCHEMBL24758197 | 0.91 | AKR1C3 (0.47) | AKR1C3AKR1C2KLKB1CARM1IRAK4 | |
| SCHEMBL24758193 | 0.90 | AKR1C3 (0.45) | NR1H2AKR1C3AKR1C2KLKB1CARM1 | |
| SCHEMBL30141424 | 0.90 | AKR1C3 (0.45) | NR1H2AKR1C3AKR1C2KLKB1CARM1 | |
| SCHEMBL24906371 | 0.90 | AKR1C3 (0.47) | AKR1C3AKR1C2KLKB1CARM1KDM4E | |
| SCHEMBL24906379 | 0.90 | AKR1C3 (0.47) | AKR1C3AKR1C2KLKB1CARM1KDM4E | |
| SCHEMBL24757352 | 0.85 | NR1H2 (0.41) | NR1H2AKR1C3AKR1C2ELANEKLKB1 | |
| SCHEMBL24758196 | 0.85 | AKR1C3 (0.41) | AKR1C3AKR1C2KLKB1CARM1CREBBP | |
| SCHEMBL30141321 | 0.85 | AKR1C3 (0.41) | AKR1C3AKR1C2KLKB1CARM1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | SCN8A, SCN1A, SCN7A | NR1H2 1438/4885AKR1C3 1950/4885AKR1C2 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.