Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.38 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24758193 | 1.00 | AKR1C3 (0.45) | AKR1C3AKR1C2CREBBPCNR2RAF1 | |
| SCHEMBL24758199 | 0.92 | AKR1C3 (0.47) | AKR1C3AKR1C2CREBBPCARM1KLKB1 | |
| SCHEMBL24758197 | 0.92 | AKR1C3 (0.47) | AKR1C3AKR1C2CREBBPCARM1KLKB1 | |
| SCHEMBL24906371 | 0.91 | AKR1C3 (0.47) | AKR1C3AKR1C2CREBBPCARM1KLKB1 | |
| SCHEMBL24906379 | 0.91 | AKR1C3 (0.47) | AKR1C3AKR1C2CREBBPCARM1KLKB1 | |
| SCHEMBL30107048 | 0.90 | NR1H2 (0.41) | AKR1C3AKR1C2CREBBPRAF1BRAF | |
| SCHEMBL24757358 | 0.90 | NR1H2 (0.41) | AKR1C3AKR1C2CREBBPRAF1BRAF | |
| SCHEMBL24906460 | 0.89 | AKR1C3 (0.45) | AKR1C3AKR1C2CREBBPCARM1KLKB1 | |
| SCHEMBL24758196 | 0.84 | AKR1C3 (0.41) | AKR1C3AKR1C2CREBBPCARM1KLKB1 | |
| SCHEMBL30141321 | 0.84 | AKR1C3 (0.41) | AKR1C3AKR1C2CREBBPCARM1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |