Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1177265 | 1.00 | TDP1 (0.46) | TDP1CYP11B1CYP11B2HTTLMNA | |
| SCHEMBL1255701 | 0.80 | HTT (0.52) | TDP1CYP11B1CYP11B2HTTLMNA | |
| SCHEMBL30475094 | 0.80 | HTT (0.52) | TDP1CYP11B1CYP11B2HTTLMNA | |
| SCHEMBL1255703 | 0.80 | HTT (0.52) | TDP1CYP11B1CYP11B2HTTLMNA | |
| SCHEMBL1177889 | 0.76 | CYP2D6 (0.49) | TDP1TSHROPRM1OPRK1OGFRL1 | |
| SCHEMBL6969625 | 0.74 | TDP1 (0.58) | TDP1CYP11B1CYP11B2HTTLMNA | |
| SCHEMBL4295876 | 0.72 | EGLN3 (0.46) | TDP1CYP11B1CYP11B2LMNATNF | |
| SCHEMBL4295875 | 0.72 | EGLN3 (0.46) | TDP1CYP11B1CYP11B2LMNATNF | |
| SCHEMBL23499140 | 0.72 | TDP1 (0.54) | TDP1CYP11B1CYP11B2HTTLMNA | |
| SCHEMBL29668645 | 0.72 | TDP1 (0.54) | TDP1CYP11B1CYP11B2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881827-B1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2011-09-28 | — | — | EP | disclosed |