Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBX7 | O95931 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | SLC5A2 | P31639 | 6/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MITF | O75030 | 1/20 | 0.65 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | IDE | P14735 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23178210 | 0.93 | CBX7 (0.71) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL12084205 | 0.91 | CBX7 (0.74) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL23178211 | 0.86 | HTT (0.60) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL23177914 | 0.85 | CBX7 (0.59) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL2497999 | 0.85 | LMNA (0.97) | HTTLMNASLC5A2NPSR1MEN1 | |
| SCHEMBL23178209 | 0.85 | CBX7 (1.00) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL23144803 | 0.83 | HTT (0.64) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL23144874 | 0.82 | CBX7 (0.55) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL23177924 | 0.82 | CBX7 (0.72) | CBX7HTTLMNASLC5A2POLB | |
| SCHEMBL23177954 | 0.81 | CBX7 (0.59) | CBX7HTTLMNASLC5A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402880-A1 | BICYCLIC INHIBITORS OF CBX CHROMODOMAINS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402880-A1 | BICYCLIC INHIBITORS OF CBX CHROMODOMAINS | CBX2, CBX3, CBX7 | CBX7 3/4885HTT 3837/4885LMNA 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.