Ramifenazone

Ramifenazone

SCHEMBL24763

Cc1c(NC(C)C)c(=O)n(-c2ccccc2)n1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2D6 P10635 1/20 1.00
GAA P10253 7/20 0.67
KMT2A Q03164 2/20 0.67
LMNA P02545 2/20 0.62
ADORA3 P0DMS8 1/20 0.62
TSHR P16473 1/20 0.61
MAPT P10636 2/20 0.59
ALDH1A1 P00352 3/20 0.59
HPGD P15428 1/20 0.59
PTGS2 P35354 1/20 0.59
TDP1 Q9NUW8 1/20 0.58
NPC1 O15118 1/20 0.57
GLA P06280 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
FPR2 P25090 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ramifenazone SCHEMBL3759490 0.98 KDM4E (0.97) KDM4ECYP1A2CYP2D6GAAKMT2A
Ramifenazone SCHEMBL1652276 0.97 KDM4E (0.94) KDM4ECYP1A2CYP2D6GAAKMT2A
SCHEMBL537958 0.82 KDM4E (0.69) KDM4ECYP1A2CYP2D6GAAKMT2A
SCHEMBL8651089 0.81 KDM4E (0.68) KDM4ECYP1A2CYP2D6GAAKMT2A
SCHEMBL18000055 0.81 KDM4E (0.68) KDM4ECYP1A2CYP2D6GAAKMT2A
SCHEMBL4447238 0.81 KDM4E (0.68) KDM4ECYP1A2CYP2D6GAAKMT2A
Magnesium SCHEMBL29732237 0.81 KDM4E (0.68) KDM4ECYP1A2CYP2D6GAAKMT2A
SCHEMBL8940124 0.81 KDM4E (0.68) KDM4ECYP1A2CYP2D6GAAKMT2A
SCHEMBL28880300 0.79 TSHR (0.81) KDM4EGAAKMT2ALMNATSHR
SCHEMBL10595695 0.79 GAA (0.77) KDM4ECYP1A2CYP2D6GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2707 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240041935-A1 PREVENTION AND TREATMENT OF REPRODUCTIVE FAILURE BY REGENERATIVE CELLS AND ADJUVANTS CREATIVE MEDICAL TECHNOLOGIES, INC. (US) 2024-02-08 US claimed
CN-117110493-A Metabolic marker associated with neonatal pneumonia and metabolic acidosis and application thereof 大连大学 2023-11-24 CN claimed
US-11819535-B2 Composition and methods for regulating extracellular matrix accumulation UNIVERSITY HEALTH NETWORK (CA) 2023-11-21 US claimed
CN-116893237-A Metabolic marker related to neonatal pneumonia and myocardial damage and application thereof 大连大学 2023-10-17 CN claimed
US-11771695-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-10-03 US claimed
US-11608532-B2 Precision medicine for treating and preventing suicidality INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2023-03-21 US claimed
EP-3385252-B1 CANNABINOID RECEPTOR MODULATORS ARENA PHARM INC (US) 2022-09-21 EP claimed
US-20220241274-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2022-08-04 US claimed
US-10991449-B2 Predicting suicidality using a combined genomic and clinical risk assessment INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2021-04-27 US claimed
US-20200318188-A1 PRECISION MEDICINE FOR TREATING AND PREVENTING SUICIDALITY INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2020-10-08 US claimed
WO-2000042050-A1 SULFATED PHOSPHATIDYLINOSITOLS, THEIR PREPARATION AND USE THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2000-07-20 WO claimed
US-6063370-A DRUG, POLYMER COMPLEX THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2000-05-16 US claimed
EP-0786999-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1999-01-20 EP claimed
EP-0792371-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1998-12-30 EP claimed
WO-1997037680-A1 MACROMOLECULAR COMPLEXES FOR DRUG DELIVERY THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1997-10-16 WO claimed
EP-0792371-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-09-03 EP claimed
EP-0786999-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-08-06 EP claimed
US-5543417-A 5 Alpha-reductase inhibitor and at least one of an antibacterial agent, a keratolytic agent or an anti-inflammatory agent MERCK & CO., INC. (US) 1996-08-06 US claimed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
WO-1996012817-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed