SCHEMBL4447238

SCHEMBL4447238

Cc1c(NS)c(=O)n(-c2ccccc2)n1C

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.68
CYP1A2 P05177 1/20 0.68
CYP2D6 P10635 1/20 0.68
TSHR P16473 1/20 0.64
MAPT P10636 3/20 0.62
TDP1 Q9NUW8 1/20 0.61
GAA P10253 8/20 0.59
ALDH1A1 P00352 4/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
GLA P06280 1/20 0.59
BCHE P06276 1/20 0.58
PTGS2 P35354 1/20 0.58
ALOX15 P16050 1/20 0.58
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
POLB P06746 1/20 0.58
LMNA P02545 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL537958 0.85 KDM4E (0.69) KDM4ECYP1A2CYP2D6TSHRMAPT
SCHEMBL18000055 0.83 KDM4E (0.68) KDM4ECYP1A2CYP2D6TSHRMAPT
Magnesium SCHEMBL29732237 0.83 KDM4E (0.68) KDM4ECYP1A2CYP2D6TSHRMAPT
SCHEMBL8651089 0.83 KDM4E (0.68) KDM4ECYP1A2CYP2D6TSHRMAPT
SCHEMBL28880300 0.82 TSHR (0.81) KDM4ETSHRMAPTGAAALDH1A1
SCHEMBL10595695 0.82 GAA (0.77) KDM4ECYP1A2CYP2D6TSHRMAPT
Ramifenazone SCHEMBL24763 0.81 KDM4E (1.00) KDM4ECYP1A2CYP2D6TSHRMAPT
SCHEMBL14326157 0.81 KDM4E (0.64) KDM4ECYP1A2CYP2D6TSHRMAPT
SCHEMBL6812409 0.81 KDM4E (0.64) KDM4ECYP1A2CYP2D6TSHRMAPT
SCHEMBL8940421 0.81 GAA (0.65) KDM4ECYP1A2CYP2D6TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1792189-B1 TEST DEVICE FOR DETERMINING THE CONCENTRATION OF LDL-CHOLESTEROL IN A SAMPLE SCHEURINGER KIM (AT) 2013-03-13 EP disclosed
US-7491542-B2 Test device for determining the concentration of LDL-cholesterol in a sample SCHEURINGER KIM 2009-02-17 US disclosed
EP-1792189-A1 TEST DEVICE FOR DETERMINING THE CONCENTRATION OF LDL-CHOLESTEROL IN A SAMPLE Scheuringer, Kim (AT) 2007-06-06 EP disclosed
WO-2006027283-A1 TEST DEVICE FOR DETERMINING THE CONCENTRATION OF LDL-CHOLESTEROL IN A SAMPLE SCHEURINGER KIM (AT) 2006-03-16 WO disclosed
US-20060008914-A1 Test device for determining the concentration of LDL-cholesterol in a sample SCHEURINGER KIM 2006-01-12 US disclosed