Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26959278 | 1.00 | HDAC8 (0.43) | HDAC8HDAC6GPR119CKS1BSKP1 | |
| SCHEMBL24675569 | 1.00 | HDAC8 (0.43) | HDAC8HDAC6GPR119CKS1BSKP1 | |
| SCHEMBL28966515 | 0.86 | GPR119 (0.51) | HDAC8HDAC6GPR119CKS1BSKP1 | |
| SCHEMBL28966512 | 0.86 | GPR119 (0.51) | HDAC8HDAC6GPR119CKS1BSKP1 | |
| SCHEMBL29841788 | 0.85 | HDAC6 (0.46) | HDAC8HDAC6GPR119CKS1BSKP1 | |
| SCHEMBL26915117 | 0.85 | HDAC6 (0.46) | HDAC8HDAC6GPR119CKS1BSKP1 | |
| SCHEMBL29088932 | 0.85 | HDAC6 (0.46) | HDAC8HDAC6GPR119CKS1BSKP1 | |
| SCHEMBL26915035 | 0.85 | CHRM2 (0.40) | NR1H2NR1H3 | |
| SCHEMBL29274283 | 0.85 | CHRM2 (0.40) | NR1H2NR1H3 | |
| SCHEMBL21360407 | 0.84 | GPR119 (0.56) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083274-A | Fused ring heterocyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-116724044-A | Tri-heterocyclic compound, preparation method and application thereof | 上海湃隆生物科技有限公司 | 2023-09-08 | — | — | CN | disclosed |
| WO-2022184103-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 武汉誉祥医药科技有限公司 | 2022-09-09 | — | — | WO | disclosed |