Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 6/20 | 0.42 |
| ▸ | TIPARP | Q7Z3E1 | 13/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.39 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675519 | 0.93 | NPBWR1 (0.44) | NPBWR1TIPARPHDAC6HDAC1PARP1 | |
| SCHEMBL26915108 | 0.93 | NPBWR1 (0.44) | NPBWR1TIPARPHDAC6HDAC1PARP1 | |
| SCHEMBL24640392 | 0.90 | NPBWR1 (0.44) | NPBWR1TIPARPHDAC6HDAC1PARP1 | |
| SCHEMBL21522522 | 0.90 | NPBWR1 (0.44) | NPBWR1TIPARPHDAC6HDAC1PARP1 | |
| SCHEMBL24962319 | 0.90 | NPBWR1 (0.44) | NPBWR1MCHR1UCHL1 | |
| SCHEMBL21522519 | 0.90 | NPBWR1 (0.44) | NPBWR1TIPARPHDAC6HDAC1PARP1 | |
| SCHEMBL29841850 | 0.88 | NPBWR1 (0.42) | NPBWR1TIPARPMCHR1UCHL1 | |
| SCHEMBL29841862 | 0.88 | NPBWR1 (0.42) | NPBWR1TIPARPMCHR1UCHL1 | |
| SCHEMBL23304574 | 0.88 | NPBWR1 (0.42) | NPBWR1TIPARPMCHR1UCHL1 | |
| SCHEMBL23304575 | 0.88 | NPBWR1 (0.42) | NPBWR1TIPARPMCHR1UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022184103-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 武汉誉祥医药科技有限公司 | 2022-09-09 | — | — | WO | disclosed |