Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.38 |
| ▸ | MTOR | P42345 | 8/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247784 | 0.71 | PIK3CA (0.38) | PIK3CAMTORCNR2ALDH1A1CYP1A2 | |
| SCHEMBL15543262 | 0.70 | ALDH1A1 (0.48) | PIK3CAMTORCNR2KMOALDH1A1 | |
| SCHEMBL29745217 | 0.70 | ALDH1A1 (0.48) | PIK3CAMTORCNR2KMOALDH1A1 | |
| SCHEMBL247209 | 0.69 | LRRK2 (0.43) | PIK3CAMTORCNR2KMOCYP2C19 | |
| SCHEMBL246131 | 0.67 | CYP2C19 (0.59) | PIK3CAMTORALDH1A1CYP1A2MAPT | |
| SCHEMBL14840567 | 0.67 | PIK3CA (0.39) | PIK3CAMTORCNR2KMOALDH1A1 | |
| SCHEMBL246534 | 0.66 | ALDH1A1 (0.44) | PIK3CAMTORCNR2KMOALDH1A1 | |
| SCHEMBL14910307 | 0.66 | KDM4E (0.47) | PIK3CAMTORCNR2KMOALDH1A1 | |
| SCHEMBL21246773 | 0.66 | CNR2 (0.52) | PIK3CACNR2ALDH1A1CYP1A2MAPT | |
| SCHEMBL245708 | 0.66 | PIK3CA (0.47) | PIK3CAMTORCNR2KMOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |