Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1525859 | 0.85 | ALDH1A1 (0.55) | CYP2A6KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL18720407 | 0.78 | CYP2A6 (0.50) | CYP2A6KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL1520214 | 0.71 | ERCC1 (0.66) | KDM4ESMN1; SMN2ALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL5836151 | 0.70 | POLB (0.41) | CYP2A6KDM4EHTTALDH1A1HPGD | |
| SCHEMBL31711447 | 0.70 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2713434 | 0.70 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL327664 | 0.70 | CYP2A6 (0.53) | CYP2A6KDM4EGAAALDH1A1HPGD | |
| SCHEMBL21038794 | 0.68 | CYP2A6 (0.61) | CYP2A6KDM4EGAAALDH1A1HPGD | |
| SCHEMBL5836360 | 0.67 | ALDH1A1 (0.57) | CYP2A6KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL14732490 | 0.67 | CYP2A6 (0.46) | CYP2A6KDM4EALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356185-A1 | MERTK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356185-A1 | MERTK DEGRADERS AND USES THEREOF | MERTK, ITK, CRKL | CYP2A6 379/4885KDM4E 542/4885SMN1; SMN2 3861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.