Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.31 |
| ▸ | MASP2 | O00187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446621 | 0.88 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL464655 | 0.88 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL445761 | 0.84 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL447714 | 0.83 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL449018 | 0.83 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL446362 | 0.82 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL445596 | 0.81 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL2476616 | 0.80 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL447290 | 0.79 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL447212 | 0.79 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370402-A2 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | Synta Pharmaceuticals Corp. (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010065512-A2 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2010-06-10 | — | — | WO | disclosed |