Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100677 | 0.97 | DDB1 (0.60) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL29991213 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL30392246 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL29991212 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL25123797 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL25123850 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL25123421 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL23842336 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL22776515 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 | |
| SCHEMBL23842179 | 0.97 | DDB1 (0.59) | CRBNDDB1SIGMAR1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731309-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| US-20260042762-A1 | MERTK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS INC (US) | 2026-02-12 | — | — | US | disclosed |
| US-12404285-B2 | KRAS G12D proteolysis targeting chimeras | PAQ Therapeutics Inc. (US) | 2025-09-02 | — | — | US | disclosed |
| US-20250051364-A1 | KRAS G12D Proteolysis Targeting Chimeras | PAQ Therapeutics Inc. (US) | 2025-02-13 | — | — | US | disclosed |
| WO-2024263586-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | PAQ Therapeutics Inc. (US) | 2024-12-26 | — | — | WO | disclosed |
| US-20240247000-A1 | KRAS G12D Proteolysis Targeting Chimeras | PAQ Therapeutics Inc. (US) | 2024-07-25 | — | — | US | disclosed |
| WO-2023215906-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | HANGZHOU JIJING PHARMACEUTICALTECHNOLOGY LIMITED (CN) | 2023-11-09 | — | — | WO | disclosed |
| US-20220356185-A1 | MERTK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-11-10 | — | — | US | disclosed |
| US-20220356185-A1 | MERTK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250051364-A1 | KRAS G12D Proteolysis Targeting Chimeras | KRAS, NRAS, HRAS | CRBN 51/4885DDB1 1063/4885SIGMAR1 4867/4885 |
| US-12404285-B2 | KRAS G12D proteolysis targeting chimeras | KRAS, NRAS, HRAS | CRBN 51/4885DDB1 1063/4885SIGMAR1 4867/4885 |
| US-20260042762-A1 | MERTK DEGRADERS AND USES THEREOF | MERTK, CRKL, OSTC | CRBN 39/4885DDB1 2712/4885SIGMAR1 271/4885 |
| US-20220356185-A1 | MERTK DEGRADERS AND USES THEREOF | MERTK, ITK, CRKL | CRBN 183/4885DDB1 3837/4885SIGMAR1 2516/4885 |
| US-20240247000-A1 | KRAS G12D Proteolysis Targeting Chimeras | KRAS, NRAS, HRAS | CRBN 51/4885DDB1 1063/4885SIGMAR1 4867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.