Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766049 | 0.80 | ROCK2 (0.40) | AKT1PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL29434090 | 0.80 | ROCK2 (0.40) | AKT1PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL24851269 | 0.72 | USP2 (0.54) | USP2SMN1; SMN2SUV39H2PIK3CAPIK3CD | |
| SCHEMBL24312197 | 0.71 | AKT1 (0.43) | USP2KIF18ASUV39H2AKT1TSHR | |
| SCHEMBL24312255 | 0.69 | AKT1 (0.39) | ATRSMN1; SMN2KIF18ASUV39H2AKT1 | |
| SCHEMBL18153347 | 0.69 | PIK3CA (0.53) | USP2SMN1; SMN2PIK3CAPIK3R1PIK3CD | |
| SCHEMBL1497394 | 0.69 | SMN1; SMN2 (0.49) | USP2SMN1; SMN2SUV39H2AKT1PIK3CA | |
| SCHEMBL29434915 | 0.69 | PIK3CA (0.53) | USP2SMN1; SMN2PIK3CAPIK3R1PIK3CD | |
| SCHEMBL3997637 | 0.69 | PIK3CA (0.53) | USP2SMN1; SMN2PIK3CAPIK3R1PIK3CD | |
| SCHEMBL21166287 | 0.68 | AKT1 (0.43) | USP2SMN1; SMN2AKT1PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11407737-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11407737-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | ATR 493/4885USP2 1597/4885SMN1; SMN2 3700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.