Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 8/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480415 | 0.93 | TACR3 (0.51) | TACR3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2478849 | 0.91 | TACR3 (0.51) | TACR3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2482572 | 0.89 | TACR3 (0.63) | TACR3 | |
| SCHEMBL2478511 | 0.86 | TACR3 (0.51) | TACR3 | |
| SCHEMBL2480492 | 0.85 | SLC6A2 (0.59) | TACR3SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL2477546 | 0.82 | TACR3 (0.55) | TACR3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2480969 | 0.80 | TACR3 (0.62) | TACR3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2477184 | 0.79 | TACR3 (0.65) | TACR3 | |
| SCHEMBL2478297 | 0.77 | TACR3 (0.67) | TACR3 | |
| SCHEMBL2479387 | 0.77 | TACR3 (0.67) | TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656349-B1 | CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2011-10-12 | — | — | EP | disclosed |