Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.40 |
| ▸ | LGMN | Q99538 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766540 | 1.00 | AKT1 (0.45) | AKT1PIK3CATSHRUSP2TDP1 | |
| SCHEMBL29434079 | 0.83 | MAPT (0.41) | AKT1PIK3CATSHRUSP2TDP1 | |
| SCHEMBL29434081 | 0.83 | MAPT (0.41) | AKT1PIK3CATSHRUSP2TDP1 | |
| SCHEMBL24766573 | 0.75 | MAPT (0.42) | PIK3CATSHRUSP2TDP1NPC1 | |
| SCHEMBL24766022 | 0.74 | AKT1 (0.46) | AKT1PIK3CATSHRUSP2TDP1 | |
| SCHEMBL29434092 | 0.74 | AKT1 (0.46) | AKT1PIK3CATSHRUSP2TDP1 | |
| SCHEMBL14842201 | 0.72 | CA1 (0.38) | MEN1KMT2AL3MBTL1KDM4EGAA | |
| SCHEMBL24766538 | 0.72 | AKT1 (0.47) | AKT1PIK3CATSHRUSP2TDP1 | |
| SCHEMBL24739780 | 0.71 | TDP1 (0.38) | TDP1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL29879874 | 0.71 | TDP1 (0.38) | TDP1MEN1KMT2AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11407737-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11407737-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | AKT1 38/4885PIK3CA 61/4885TSHR 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.