Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | FECH | P22830 | 1/20 | 0.36 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30575827 | 0.87 | EGFR (0.45) | EGFRMKNK2ERBB2NQO2FECH | |
| SCHEMBL25430634 | 0.87 | EGFR (0.45) | EGFRMKNK2ERBB2NQO2FECH | |
| SCHEMBL30127392 | 0.82 | EGFR (0.47) | EGFRMKNK2ERBB2NQO2FECH | |
| SCHEMBL30127072 | 0.82 | EGFR (0.47) | EGFRMKNK2ERBB2NQO2FECH | |
| SCHEMBL24167293 | 0.80 | EGFR (0.52) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24569376 | 0.80 | KDM4E (0.53) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL29888339 | 0.80 | KDM4E (0.53) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24569439 | 0.76 | ERBB2 (0.61) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL29888106 | 0.76 | ERBB2 (0.61) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL29887854 | 0.76 | ERBB2 (0.61) | EGFRERBB2NQO2FECHMYH14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |