Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24167293 | 0.90 | EGFR (0.52) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24569385 | 0.86 | EGFR (0.49) | KDM4EMEN1KMT2AALKALDH1A1 | |
| SCHEMBL24168089 | 0.84 | ALK (0.58) | MEN1KMT2AALKALDH1A1L3MBTL1 | |
| SCHEMBL24167891 | 0.81 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL24767919 | 0.80 | EGFR (0.47) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL24167454 | 0.79 | EGFR (0.41) | KDM4EALDH1A1LMNANPC1NCOA1 | |
| SCHEMBL24569380 | 0.79 | EGFR (0.39) | MAPTHTTMAPK1AHREGFR | |
| Hydrochloric Acid SCHEMBL8933828 | 0.79 | KDM4E (0.64) | KDM4EMEN1KMT2AALKALDH1A1 | |
| SCHEMBL24168088 | 0.79 | EGFR (0.53) | EGFRERBB2 | |
| SCHEMBL24569870 | 0.77 | HTT (0.55) | KDM4EALDH1A1LMNANCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |