Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24775075 | 0.92 | KDM4E (0.44) | SMN1; SMN2ALDH1A1KDM4ENPY1RNPY2R | |
| SCHEMBL24775076 | 0.88 | HTR2C (0.39) | SMN1; SMN2ALDH1A1KDM4ENPY1RNPY2R | |
| SCHEMBL24775174 | 0.85 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ALDH1A1LMNADRD2 | |
| SCHEMBL24775072 | 0.85 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ALDH1A1LMNADRD2 | |
| SCHEMBL24775175 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL24775070 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL24774524 | 0.83 | ADRA1A (0.41) | HSP90AA1HSP90AB1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL24774525 | 0.82 | HTR2A (0.40) | SMN1; SMN2CHRNB4CHRNA3LMNAADRA1D | |
| SCHEMBL24774520 | 0.82 | HCRTR2 (0.46) | DRD2 | |
| SCHEMBL24775068 | 0.82 | HTR2A (0.40) | SMN1; SMN2CHRNB4CHRNA3LMNAADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002369-A1 | Bcl-2 INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2023-01-05 | — | — | US | disclosed |
| US-20220402915-A1 | BCL-2 INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2022-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402915-A1 | BCL-2 INHIBITORS | BCL2, BCL2L1, BCL2L2 | HSP90AA1 444/4885HSP90AB1 160/4885SMN1; SMN2 1818/4885 |
| US-20230002369-A1 | Bcl-2 INHIBITORS | BCL2, BCL2L1, BCL2L2 | HSP90AA1 444/4885HSP90AB1 160/4885SMN1; SMN2 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.