Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20469229 | 0.77 | CACNA1G (0.41) | PAX8CACNA1GCACNA1BCACNA1CAAK1 | |
| SCHEMBL1929153 | 0.77 | HTR2C (0.42) | GBA1PAX8CACNA1GCACNA1BCACNA1C | |
| SCHEMBL2477577 | 0.74 | AAK1 (0.36) | PAX8AAK1 | |
| SCHEMBL9980531 | 0.74 | AAK1 (0.36) | PAX8AAK1 | |
| SCHEMBL20456732 | 0.72 | CACNA1G (0.38) | PAX8CACNA1GCACNA1BCACNA1CHTR2C | |
| SCHEMBL6812673 | 0.71 | CACNA1G (0.42) | PAX8CACNA1GCACNA1BCACNA1CHTR2C | |
| SCHEMBL21334068 | 0.70 | AAK1 (0.31) | PAX8AAK1 | |
| SCHEMBL29602667 | 0.70 | GBA1 (0.42) | GBA1PAX8CACNA1GCACNA1BCACNA1C | |
| SCHEMBL18731533 | 0.70 | SSTR4 (0.39) | PAX8 | |
| SCHEMBL21334151 | 0.70 | AAK1 (0.30) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373167-A1 | INHIBITORS OF HCV NS5A | Presidio Pharmaceuticals, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065668-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |