Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24778749 | 0.83 | PDGFRB (0.38) | LMNAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL30290991 | 0.83 | PDGFRB (0.38) | LMNAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL24779889 | 0.79 | PDGFRB (0.45) | LMNAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL19172750 | 0.77 | PDK1 (0.38) | ALDH1A1PDK1KMT2A | |
| SCHEMBL4652294 | 0.77 | MYC (0.46) | LMNAVCAM1ALDH1A1PDK1MAPT | |
| SCHEMBL19171753 | 0.74 | PDK1 (0.36) | LMNAALDH1A1PKMPDK1KMT2A | |
| SCHEMBL15514790 | 0.73 | POLB (0.43) | LMNAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL15440170 | 0.69 | PDGFRB (0.45) | LMNAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1560385 | 0.69 | AR (0.58) | LMNAVCAM1ALDH1A1PKMPDK1 | |
| SCHEMBL28317018 | 0.69 | PDK1 (0.69) | LMNAVCAM1ALDH1A1PDK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020522-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 | ARVINAS OPERATIONS, INC. (US) | 2024-01-25 | — | — | WO | disclosed |
| WO-2022266258-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 | ARVINAS OPERATIONS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |