Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 4/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | NPY1R | P25929 | 2/20 | 0.38 |
| ▸ | TACR2 | P21452 | 5/20 | 0.38 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2477401 | 0.88 | TACR3 (0.44) | TACR3HSD11B1MEN1KMT2ADRD2 | |
| SCHEMBL2480350 | 0.87 | TACR3 (0.67) | TACR3HSD11B1MEN1KMT2ATACR2 | |
| SCHEMBL2477412 | 0.85 | TACR3 (0.60) | TACR3HSD11B1TACR2TACR1 | |
| SCHEMBL2479040 | 0.84 | TACR3 (0.51) | TACR3DRD2DRD4TACR2TACR1 | |
| SCHEMBL2482748 | 0.84 | TACR3 (0.51) | TACR3DRD2DRD4TACR2TACR1 | |
| SCHEMBL2477155 | 0.84 | TACR2 (0.53) | TACR3TACR2TACR1 | |
| SCHEMBL2478061 | 0.84 | TACR2 (0.53) | TACR3TACR2TACR1 | |
| SCHEMBL2476377 | 0.80 | TACR3 (0.75) | TACR3TACR2TACR1 | |
| SCHEMBL2480965 | 0.80 | TACR3 (0.75) | TACR3TACR2TACR1 | |
| SCHEMBL2477355 | 0.80 | TACR3 (0.75) | TACR3TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656349-B1 | CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2011-10-12 | — | — | EP | claimed |