SCHEMBL24782856

SCHEMBL24782856

CNc1ccc2ncnn2n1

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FYN P06241 11/20 0.41
MKNK1 Q9BUB5 2/20 0.40
MAP4K4 O95819 1/20 0.33
EGLN2 Q96KS0 1/20 0.31
HCAR3 P49019 1/20 0.31
NCF1 P14598 1/20 0.31
NNMT P40261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21646374 0.80 MAP4K4 (0.37) FYNMAP4K4HCAR3
SCHEMBL24783510 0.80 ADRA2A (0.37) FYNMAP4K4EGLN2HCAR3
SCHEMBL6619928 0.74 MKNK1 (0.47) FYNMKNK1
SCHEMBL10490728 0.73 DYRK1A (0.40) FYNEGLN2
SCHEMBL6617917 0.71 KDM4E (0.34) MKNK1
SCHEMBL6619537 0.70 FYN (0.45) FYNMKNK1
SCHEMBL434468 0.69 KDM4E (0.41) EGLN2
SCHEMBL10490611 0.69 DYRK3 (0.37) EGLN2
SCHEMBL23034388 0.69 HTT (0.31) EGLN2
SCHEMBL3894870 0.69 HTT (0.53) FYNMKNK1NCF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230109839-A1 THERAPEUTIC AGENT FOR TAUOPATHIES Sumitomo Pharma Co., Ltd. (JP) 2023-04-13 US disclosed
EP-4104861-A1 THERAPEUTIC AGENT FOR TAUOPATHIES Sumitomo Pharma Co., Ltd. (JP) 2022-12-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230109839-A1 THERAPEUTIC AGENT FOR TAUOPATHIES MAPT, PSEN1, PSEN2 FYN 286/4885MKNK1 641/4885MAP4K4 902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.