Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.86 |
| ▸ | KDR | P35968 | 3/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | ARAF | P10398 | 2/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL940018 | 0.93 | RAF1 (1.00) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL2480623 | 0.89 | RAF1 (0.84) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL549001 | 0.89 | RAF1 (1.00) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL548328 | 0.86 | RAF1 (0.79) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL13471762 | 0.83 | RAF1 (0.84) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL937568 | 0.82 | RAF1 (1.00) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL3707691 | 0.82 | RAF1 (0.83) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL2507080 | 0.82 | RAF1 (0.75) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL3181311 | 0.81 | RAF1 (0.70) | RAF1KDRPDGFRBGSK3BARAF | |
| SCHEMBL13471761 | 0.81 | RAF1 (0.84) | RAF1KDRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1580188-B9 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-23 | — | — | EP | claimed |
| EP-1580188-B1 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2011-10-19 | — | — | EP | claimed |