Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.75 |
| ▸ | KDR | P35968 | 6/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | FRK | P42685 | 2/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.59 |
| ▸ | BLK | P51451 | 2/20 | 0.59 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549001 | 0.86 | RAF1 (1.00) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL548328 | 0.85 | RAF1 (0.79) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL940018 | 0.84 | RAF1 (1.00) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL2478377 | 0.82 | RAF1 (0.86) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL3181311 | 0.81 | RAF1 (0.70) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL1506420 | 0.79 | RAF1 (0.86) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL5082237 | 0.78 | RAF1 (0.83) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL6127281 | 0.77 | RAF1 (0.68) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL13946049 | 0.77 | RAF1 (0.71) | RAF1KDRAURKBPLK4AURKA | |
| SCHEMBL1506452 | 0.77 | RAF1 (0.82) | RAF1KDRAURKBPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1580188-B9 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-23 | — | — | EP | disclosed |
| EP-1580188-B1 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2011-10-19 | — | — | EP | disclosed |