Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.82 |
| ▸ | YAP1 | P46937 | 1/20 | 0.82 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20779435 | 0.90 | TEAD1 (1.00) | TEAD1YAP1TNNI3KTSHRL3MBTL1 | |
| SCHEMBL29438871 | 0.90 | TEAD1 (1.00) | TEAD1YAP1TNNI3KTSHRL3MBTL1 | |
| SCHEMBL24788976 | 0.88 | TEAD1 (0.75) | TEAD1YAP1TNNI3KTSHRL3MBTL1 | |
| SCHEMBL24788980 | 0.88 | TEAD1 (0.66) | TEAD1YAP1TNNI3KBRAFTLR2 | |
| SCHEMBL30135282 | 0.88 | TEAD1 (0.66) | TEAD1YAP1TNNI3KBRAFTLR2 | |
| SCHEMBL20767258 | 0.84 | TEAD1 (0.85) | TEAD1YAP1TNNI3KTSHRL3MBTL1 | |
| SCHEMBL25790336 | 0.84 | TEAD1 (0.77) | TEAD1YAP1TNNI3KALDH3A1BRAF | |
| SCHEMBL20767350 | 0.83 | TEAD1 (0.77) | TEAD1YAP1TNNI3KTSHRL3MBTL1 | |
| SCHEMBL29901817 | 0.83 | TEAD1 (0.77) | TEAD1YAP1TNNI3KTSHRL3MBTL1 | |
| SCHEMBL22718256 | 0.83 | TEAD1 (0.80) | TEAD1YAP1TNNI3KTSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022258040-A1 | HETEROCYCLIC COMPOUND FOR TEAD INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2022-12-15 | — | — | WO | disclosed |
| CN-115466243-A | Heterocyclic compounds for TEAD inhibitors | 武汉人福创新药物研发中心有限公司 | 2022-12-13 | — | — | CN | disclosed |