Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.66 |
| ▸ | YAP1 | P46937 | 1/20 | 0.66 |
| ▸ | BRAF | P15056 | 8/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30135282 | 1.00 | TEAD1 (0.66) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL22718190 | 0.91 | TEAD1 (0.77) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL29438880 | 0.91 | TEAD1 (0.77) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24788978 | 0.89 | TEAD1 (0.61) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL30129838 | 0.89 | TEAD1 (0.61) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24788977 | 0.88 | TEAD1 (0.82) | TEAD1YAP1BRAFTNNI3KTLR2 | |
| SCHEMBL29438838 | 0.88 | TEAD1 (0.66) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL22718188 | 0.88 | TEAD1 (0.66) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL22718358 | 0.85 | TEAD1 (0.63) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL29438916 | 0.85 | TEAD1 (0.63) | TEAD1YAP1BRAFTNNI3KMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022258040-A1 | HETEROCYCLIC COMPOUND FOR TEAD INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2022-12-15 | — | — | WO | disclosed |
| CN-115466243-A | Heterocyclic compounds for TEAD inhibitors | 武汉人福创新药物研发中心有限公司 | 2022-12-13 | — | — | CN | disclosed |