Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 5/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.53 |
| ▸ | CCNH | P51946 | 4/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 6/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24792992 | 0.89 | CDK7 (0.51) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792809 | 0.89 | CDK7 (0.56) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792994 | 0.87 | CDK7 (0.60) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24793458 | 0.87 | CDK2 (0.55) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24791651 | 0.84 | CDK2 (0.60) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL30083395 | 0.84 | KCNN3 (0.40) | CDK2CCNE1GSK3BGPR39 | |
| SCHEMBL24792407 | 0.84 | CDK7 (0.68) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL20848285 | 0.82 | CDK7 (0.75) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24791493 | 0.81 | CDK2 (0.55) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792823 | 0.81 | CDK7 (0.55) | CDK7CDK2CCNE1CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |