Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 4/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2479506 | 0.88 | ROCK2 (0.35) | ROCK2 | |
| SCHEMBL2479140 | 0.83 | ROCK2 (0.38) | ROCK2 | |
| SCHEMBL2451552 | 0.79 | ROCK2 (0.43) | ROCK2TRPV1 | |
| SCHEMBL2480448 | 0.79 | ROCK2 (0.39) | ROCK2 | |
| SCHEMBL2477751 | 0.78 | MAPT (0.35) | ROCK2 | |
| SCHEMBL2444206 | 0.78 | CREBBP (0.40) | ROCK2 | |
| SCHEMBL2447040 | 0.75 | NTRK1 (0.37) | ROCK2 | |
| SCHEMBL2480700 | 0.75 | ROCK2 (0.38) | ROCK2 | |
| SCHEMBL8905533 | 0.74 | MAPT (0.44) | CDK9CCNT1ROCK2TRPV1 | |
| SCHEMBL2446341 | 0.74 | ROCK2 (0.40) | ROCK2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |