Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 1.00 |
| ▸ | PDE4A | P27815 | 11/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | VEGFA | P15692 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | PDE5A | O76074 | 1/20 | 0.65 |
| ▸ | TNF | P01375 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PDE1A | P54750 | 1/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291084 | 1.00 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7094968 | 0.93 | PDE4B (0.87) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| Hydrochloric Acid SCHEMBL3179865 | 0.92 | PDE4B (0.85) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL3648073 | 0.88 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9167416 | 0.85 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9062953 | 0.84 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7929728 | 0.81 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL4919377 | 0.81 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL3261886 | 0.81 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9772874 | 0.81 | HTR2A (0.70) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373366-A1 | INHALER | Boehringer Ingelheim International GmbH (DE) | 2011-10-12 | — | — | EP | disclosed |
| EP-2244686-A1 | METHOD AND DEVICE FOR FILLING CAPSULES | Boehringer Ingelheim International GmbH (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010063645-A1 | INHALER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-06-10 | — | — | WO | disclosed |
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009098083-A1 | METHOD AND DEVICE FOR FILLING CAPSULES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-13 | — | — | WO | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| US-5545647-A | PHOSPHODIESTERASE INHIBITORS; ANTIASTHMATICS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-08-13 | — | — | US | disclosed |
| EP-0671389-A1 | 3-Phenylpyrrolidine derivatives | Mitsubishi Chemical Corporation (JP) | 1995-09-13 | — | — | EP | disclosed |