Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.87 |
| ▸ | PDE4A | P27815 | 11/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | VEGFA | P15692 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | PDE5A | O76074 | 1/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PDE1A | P54750 | 1/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3179865 | 0.99 | PDE4B (0.85) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL2479640 | 0.93 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL30291084 | 0.93 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9167416 | 0.90 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9062953 | 0.88 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL2473309 | 0.86 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| Hydrochloric Acid SCHEMBL9014415 | 0.85 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| Hydrochloric Acid SCHEMBL9772895 | 0.85 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL7438600 | 0.83 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7408219 | 0.82 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7649095-B2 | Piperidine derivatives and agent comprising the derivative as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-01-19 | — | — | US | disclosed |
| US-7649095-B2 | Piperidine derivatives and agent comprising the derivative as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-01-19 | — | — | US | disclosed |
| US-6605618-B2 | Antidiabetic agents; hypoglycemic agents; anticholesterol agents; side effect reduction | WYETH | 2003-08-12 | — | — | US | disclosed |
| US-20030018045-A1 | Heterocyclic beta-3 adrenergic receptor agonists | WYETH (US) | 2003-01-23 | — | — | US | disclosed |
| US-6451814-B1 | SUBSTITUTED 4-((4-AMINO-5-HYDROXYPHENYL)-OXY-)PIPERIDINE ANALOGS; METABOLIC DISORDERS; ANTIDIABETIC AGENTS; ATHERO-SCLEROSIS, GASTROINTESTINAL DISORDERS, GLAUCOMA, NEUROGENETIC INFLAMMATION, OCULAR HYPERTENSION AND FREQUENT URINATION | WYETH | 2002-09-17 | — | — | US | disclosed |
| US-20020028832-A1 | Heterocyclic beta-3 adrenergic receptor agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-03-07 | — | — | US | disclosed |
| WO-2002006229-A2 | HETEROCYCLIC BETA-3 ADRENERGIC RECEPTOR AGONISTS | WYETH (US) | 2002-01-24 | — | — | WO | disclosed |
| EP-0696276-A1 | N-ACYL SUBSTITUTED PHENYL PIPERIDINES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-02-14 | — | — | EP | disclosed |
| US-5459151-A | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |
| WO-1994025437-A1 | N-ACYL SUBSTITUTED PHENYL PIPERIDINES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018045-A1 | Heterocyclic beta-3 adrenergic receptor agonists | ADRB2, ADRB1, ADRB3 | PDE4B 879/4885PDE4A 872/4885PDE4C 1515/4885 |
| US-20020028832-A1 | Heterocyclic beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | PDE4B 992/4885PDE4A 889/4885PDE4C 1481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.