Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 6/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550428 | 0.95 | ALOX5 (0.60) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL31301729 | 0.92 | HDAC3 (0.52) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL1713228 | 0.92 | ALOX5 (0.63) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL31301745 | 0.90 | ALOX5 (0.52) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL30311604 | 0.90 | ALOX5 (0.55) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL1836157 | 0.89 | ALOX5 (0.63) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL25473056 | 0.89 | HDAC3 (0.55) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL9324850 | 0.89 | SMN1; SMN2 (0.55) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL18255136 | 0.87 | TDP1 (0.49) | ALOX5LTA4HBCHEACHETDP1 | |
| SCHEMBL15270589 | 0.86 | HDAC3 (0.59) | LTA4HBCHEACHETDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376478-A2 | PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE | Novartis AG (CH) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010066684-A2 | Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease | NOVARTIS AG (CH) | 2010-06-17 | — | — | WO | disclosed |