Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 10/20 | 0.62 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.60 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18295022 | 0.86 | PTGER1 (0.64) | PTGER1P2RY14 | |
| SCHEMBL18295023 | 0.85 | GAA (0.53) | PTGER1P2RY14KMT2AMEN1TP53 | |
| SCHEMBL20344448 | 0.83 | KMT2A (0.69) | PTGER1MALT1P2RY14BRD4KMT2A | |
| SCHEMBL24798878 | 0.78 | P2RY14 (0.54) | PTGER1MALT1P2RY14BRD4KMT2A | |
| SCHEMBL4092092 | 0.78 | PTGER1 (1.00) | PTGER1 | |
| SCHEMBL18377479 | 0.76 | BAZ2B (0.51) | PTGER1MALT1BRD4KMT2AMEN1 | |
| SCHEMBL9133647 | 0.76 | AURKA (0.57) | PTGER1MALT1P2RY14KMT2AMEN1 | |
| SCHEMBL18295020 | 0.75 | PTGER1 (0.46) | PTGER1P2RY14KMT2AMEN1TP53 | |
| SCHEMBL23185566 | 0.75 | BRD4 (0.77) | PTGER1MALT1P2RY14BRD4MAPT | |
| SCHEMBL3186423 | 0.74 | SMN1; SMN2 (0.56) | P2RY14KMT2AMEN1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589618-B1 | PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-12-28 | — | — | EP | disclosed |