Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.53 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24798878 | 0.85 | P2RY14 (0.54) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL1902344 | 0.84 | MEN1 (0.78) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL3095032 | 0.84 | KMT2A (0.62) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL2077298 | 0.84 | MEN1 (0.62) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL3097099 | 0.83 | GAA (0.63) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL1897273 | 0.83 | MEN1 (0.80) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL24798019 | 0.83 | PTGER1 (0.62) | KMT2AMEN1PTGER1MALT1BAZ2B | |
| SCHEMBL3093042 | 0.82 | KMT2A (0.61) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL1899756 | 0.82 | MEN1 (1.00) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL18377479 | 0.82 | BAZ2B (0.51) | KMT2AMEN1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |