Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | RORC | P51449 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | KCNA1 | Q09470 | 4/20 | 0.35 |
| ▸ | KCNAB1 | Q14722 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24800636 | 0.92 | ROCK2 (0.44) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL24800429 | 0.91 | ROCK2 (0.43) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL19377185 | 0.87 | ROCK2 (0.43) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL19377186 | 0.87 | ROCK2 (0.43) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL19377340 | 0.87 | ROCK2 (0.43) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL19377328 | 0.87 | ROCK2 (0.43) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL19377423 | 0.86 | ROCK2 (0.43) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL19377308 | 0.86 | ROCK2 (0.43) | ROCK2RORCDRD2DRD3MLNR | |
| SCHEMBL24801213 | 0.83 | ROCK2 (0.38) | ROCK2RORCDRD2DRD3KCNA1 | |
| SCHEMBL19377191 | 0.82 | ROCK2 (0.53) | ROCK2RORCDRD2DRD3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390355-B1 | BENZENESULFONYL-ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2022-12-28 | — | — | EP | disclosed |