Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 17/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437689 | 1.00 | GHSR (0.58) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| Hydrochloric Acid SCHEMBL2433952 | 0.99 | GHSR (0.57) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2434584 | 0.81 | GHSR (0.68) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2439662 | 0.81 | GHSR (0.46) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| Hydrochloric Acid SCHEMBL17220632 | 0.80 | GHSR (0.46) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| Hydrochloric Acid SCHEMBL2431913 | 0.80 | GHSR (0.46) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12328326 | 0.78 | GHSR (0.58) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12299412 | 0.78 | GHSR (0.58) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| Hydrochloric Acid SCHEMBL2435615 | 0.77 | GHSR (0.57) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| Hydrochloric Acid SCHEMBL2447325 | 0.77 | GHSR (0.57) | GHSRCHRM2CYP3A4HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609680-B2 | 2,3-dihydro-1H-inden-1-yl-2,7-diazaspiro[3.5] nonane derivatives | PFIZER INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | PFIZER INC. | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | GIPR, GLP1R, GHSR | GHSR 3/4885CHRM2 826/4885CYP3A4 4410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.