Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CTSD | P07339 | 1/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24568217 | 1.00 | HPGD (0.68) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL18893131 | 0.88 | L3MBTL1 (0.74) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL30848409 | 0.87 | HPGD (0.64) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL8029750 | 0.85 | HPGD (0.69) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| Alcohol SCHEMBL6836623 | 0.83 | L3MBTL1 (0.68) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL9830660 | 0.83 | HPGD (0.67) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL9830652 | 0.83 | HPGD (0.67) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL2251625 | 0.82 | HPGD (0.70) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL2792267 | 0.82 | HPGD (0.70) | HPGDALDH1A1L3MBTL1CTSDSTAT3 | |
| SCHEMBL2251629 | 0.82 | HPGD (0.70) | HPGDALDH1A1L3MBTL1CTSDSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207267-A1 | (R)-Glutarimide CRBN Ligands and Methods of Use | BEIGENE SWITZERLAND GMBH (CH) | 2024-06-27 | — | — | US | disclosed |
| US-20240207267-A1 | (R)-Glutarimide CRBN Ligands and Methods of Use | BEIGENE SWITZERLAND GMBH (CH) | 2024-06-27 | — | — | US | disclosed |
| WO-2022268052-A9 | (R) -GLUTARIMIDE CRBN LIGANDS AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-08-17 | — | — | WO | disclosed |
| WO-2022268052-A1 | (R) -GLUTARIMIDE CRBN LIGANDS AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240207267-A1 | (R)-Glutarimide CRBN Ligands and Methods of Use | CRBN, CDR2, CRKL | HPGD 1922/4885ALDH1A1 2445/4885L3MBTL1 2113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.