Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480174 | 0.90 | ADORA1 (0.49) | BCHEMAPTKDM4ENPC1MAPK1 | |
| SCHEMBL666370 | 0.81 | MAPK8 (0.49) | BCHEMAOAMAPTKDM4ENPC1 | |
| SCHEMBL1118990 | 0.71 | DRD4 (0.45) | BCHEDRD4NPY5RCYP2A6MAOA | |
| SCHEMBL2477067 | 0.70 | KDM4E (0.53) | NPY5RMAOAMAOBMAPTKDM4E | |
| SCHEMBL467763 | 0.69 | DRD4 (0.50) | BCHEDRD4NPY5RCYP2A6MAOA | |
| SCHEMBL4288204 | 0.69 | ADORA1 (0.79) | BCHEMAPTKDM4ENPC1MAPK1 | |
| SCHEMBL12177816 | 0.69 | ADORA1 (0.53) | BCHEDRD4NPY5RCYP2A6MAOA | |
| SCHEMBL30953858 | 0.69 | ADORA1 (0.79) | BCHEMAPTKDM4ENPC1MAPK1 | |
| SCHEMBL30505637 | 0.69 | CYP2A6 (0.68) | BCHEDRD4NPY5RCYP2A6MAOA | |
| SCHEMBL3103992 | 0.69 | CYP2A6 (0.68) | BCHEDRD4NPY5RCYP2A6MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349857-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2013-01-08 | — | — | US | claimed |
| US-20070244130-A1 | Compounds and Compositions as Ppar Modulators | IRM LLC (BM) | 2007-10-18 | — | — | US | claimed |
| US-20070203155-A1 | Compounds And Compositions As Ppar Modulators | IRM LLC (BM) | 2007-08-30 | — | — | US | claimed |
| US-20070191371-A1 | HETEROCYCLIC MODULATORS OF PPAR | KALYPSYS, INC. (US) | 2007-08-16 | — | — | US | claimed |
| US-9951051-B2 | Process for producing alkynylketone derivative | SHIONOGI & CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-20170197943-A1 | PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-13 | — | — | US | disclosed |
| EP-3150573-A1 | METHOD FOR PRODUCING ALKYNYL KETONE DERIVATIVE | Shionogi & Co., Ltd. (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-1854789-B1 | QUINAZOLINE DERIVATIVE HAVING TYROSINE KINASE INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2013-10-09 | — | — | EP | disclosed |
| US-8426589-B2 | Process for production of quinazoline derivative | SHIONOGI & CO., LTD. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-8349857-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2013-01-08 | — | — | US | disclosed |
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |
| US-20120123114-A1 | QUINAZOLINE DERIVATIVES HAVING TYROSINE KINASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-20070191371-A1 | HETEROCYCLIC MODULATORS OF PPAR | KALYPSYS, INC. (US) | 2007-08-16 | — | — | US | disclosed |
| EP-1749003-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2007-02-07 | — | — | EP | disclosed |
| US-7169931-B2 | Cell differentiation, cell proliferation | SHIONOGI & CO., LTD. (JP) | 2007-01-30 | — | — | US | disclosed |
| WO-2005116016-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2005-12-08 | — | — | WO | disclosed |
| US-20040082626-A1 | Cyclic compounds exhibiting thrombopoietin receptor agonism | SHIONOGI & CO., LTD. (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1361220-A1 | CYCLIC COMPOUNDS HAVING THROMBOPOIETIN RECEPTOR AGONISM | SHIONOGI & CO., LTD. (JP) | 2003-11-12 | — | — | EP | disclosed |
| US-20030195231-A1 | Compounds exhibiting thrombopoietin receptor agonism | SHIONOGI & CO., LTD. (JP) | 2003-10-16 | — | — | US | disclosed |
| EP-1253142-A1 | COMPOUNDS EXHIBITING THROMBOPOIETIN RECEPTOR AGONISM | SHIONOGI & CO., LTD. (JP) | 2002-10-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191371-A1 | HETEROCYCLIC MODULATORS OF PPAR | PPARG, PPARD, PPARA | BCHE 3280/4885DRD4 3285/4885NPY5R 1318/4885 |
| US-20070203155-A1 | Compounds And Compositions As Ppar Modulators | PPARG, PPARA, PPARD | BCHE 3613/4885DRD4 3269/4885NPY5R 2381/4885 |
| US-20030195231-A1 | Compounds exhibiting thrombopoietin receptor agonism | MPL, TEK, NPY1R | BCHE 4366/4885DRD4 2552/4885NPY5R 51/4885 |
| US-20040082626-A1 | Cyclic compounds exhibiting thrombopoietin receptor agonism | TEK, MPL, NPY1R | BCHE 4094/4885DRD4 3244/4885NPY5R 38/4885 |
| US-20120123114-A1 | QUINAZOLINE DERIVATIVES HAVING TYROSINE KINASE INHIBITORY ACTIVITY | ERBB2, EGFR, ABL1 | BCHE 3782/4885DRD4 1075/4885NPY5R 97/4885 |
| US-20170197943-A1 | PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE | PDK4, PDK3, PDK2 | BCHE 3948/4885DRD4 923/4885NPY5R 2804/4885 |
| US-20070244130-A1 | Compounds and Compositions as Ppar Modulators | PPARG, PPARA, PPARD | BCHE 3613/4885DRD4 3269/4885NPY5R 2381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.