Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARS1 | P26639 | 2/20 | 0.66 |
| ▸ | JAK3 | P52333 | 13/20 | 0.41 |
| ▸ | JAK1 | P23458 | 11/20 | 0.41 |
| ▸ | JAK2 | O60674 | 11/20 | 0.41 |
| ▸ | TYK2 | P29597 | 9/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 4/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30151465 | 1.00 | TARS1 (0.66) | TARS1JAK3JAK1JAK2TYK2 | |
| SCHEMBL24804179 | 0.82 | ESR2 (0.53) | TARS1JAK3JAK1JAK2TYK2 | |
| SCHEMBL24804176 | 0.81 | TARS1 (0.62) | TARS1JAK3JAK1JAK2TYK2 | |
| SCHEMBL30446213 | 0.80 | TARS1 (0.50) | TARS1ENPP1 | |
| SCHEMBL20782528 | 0.80 | TARS1 (0.50) | TARS1ENPP1 | |
| SCHEMBL30336748 | 0.79 | ENPP1 (0.47) | ROCK1ENPP1 | |
| SCHEMBL25546555 | 0.79 | ENPP1 (0.47) | ROCK1ENPP1 | |
| SCHEMBL24000619 | 0.77 | ENPP1 (0.42) | TARS1ROCK1ENPP1 | |
| SCHEMBL30088818 | 0.77 | ENPP1 (0.42) | TARS1ROCK1ENPP1 | |
| SCHEMBL30337022 | 0.77 | ENPP1 (0.42) | TARS1ROCK1ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411420-A1 | PYRROLOPYRIMIDINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE INHIBITORY ACTIVITY AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2022-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411420-A1 | PYRROLOPYRIMIDINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE INHIBITORY ACTIVITY AND USE THEREOF | ENPP1, ENPP3, PPA1 | TARS1 330/4885JAK3 4097/4885JAK1 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.