Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 7/20 | 0.52 |
| ▸ | MELK | Q14680 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.46 |
| ▸ | MERTK | Q12866 | 3/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24805255 | 0.85 | IKBKB (0.65) | ENPP1JAK2IKBKBCHUKJAK3 | |
| SCHEMBL24804945 | 0.81 | JAK2 (0.63) | JAK2JAK3MELKBTKJAK1 | |
| SCHEMBL24804206 | 0.79 | ENPP1 (0.56) | ENPP1JAK2IKBKBCHUKJAK3 | |
| SCHEMBL24805930 | 0.79 | JAK3 (0.65) | ENPP1JAK2IKBKBCHUKJAK3 | |
| SCHEMBL24805935 | 0.79 | CA12 (0.53) | JAK2IKBKBCHUKJAK3MELK | |
| SCHEMBL24804174 | 0.75 | JAK3 (0.53) | JAK2JAK3MELKBTKJAK1 | |
| SCHEMBL13885161 | 0.74 | JAK2 (0.69) | JAK2IKBKBCHUKJAK3MELK | |
| SCHEMBL4582666 | 0.72 | JAK2 (0.67) | JAK2IKBKBCHUKJAK3MELK | |
| SCHEMBL4582660 | 0.72 | JAK2 (0.67) | JAK2IKBKBCHUKJAK3MELK | |
| SCHEMBL15661937 | 0.72 | JAK2 (0.67) | JAK2IKBKBCHUKJAK3MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411420-A1 | PYRROLOPYRIMIDINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE INHIBITORY ACTIVITY AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2022-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411420-A1 | PYRROLOPYRIMIDINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE INHIBITORY ACTIVITY AND USE THEREOF | ENPP1, ENPP3, PPA1 | ENPP1 1/4885JAK2 3603/4885IKBKB 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.