Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 3/20 | 0.33 |
| ▸ | TTK | P33981 | 3/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSH | P09668 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30862166 | 1.00 | KMT2A (0.38) | KMT2AHASPINOPRK1NQO2MEN1 | |
| SCHEMBL25903681 | 0.78 | NQO2 (0.43) | KMT2AOPRK1NQO2MEN1NPC1 | |
| SCHEMBL30527151 | 0.78 | NQO2 (0.43) | KMT2AOPRK1NQO2MEN1NPC1 | |
| SCHEMBL31082619 | 0.76 | TP53 (0.42) | KMT2AMEN1ALDH1A1THRBRXFP1 | |
| SCHEMBL25096317 | 0.76 | TP53 (0.42) | KMT2AMEN1ALDH1A1THRBRXFP1 | |
| SCHEMBL1635008 | 0.75 | NQO2 (0.41) | KMT2AOPRK1NQO2MEN1NPC1 | |
| SCHEMBL30862165 | 0.73 | HASPIN (0.33) | HASPIN | |
| SCHEMBL24810080 | 0.73 | HASPIN (0.33) | HASPIN | |
| SCHEMBL26341085 | 0.72 | MEN1 (0.38) | KMT2AHASPINMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL13271289 | 0.71 | METAP2 (0.50) | KMT2AHASPINMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117836286-A | Heterocyclic EGFR inhibitors for the treatment of cancer | 缆图药品公司 | 2024-04-05 | — | — | CN | disclosed |
| WO-2022271613-A1 | HETEROCYCLIC EGFR INHIBITORS FOR USE IN THE TREATMENT OF CANCER | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |