Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246127 | 0.80 | HSD17B10 (0.45) | MAPTALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL248609 | 0.80 | ADORA1 (0.40) | NPC1KDM4EIKBKBCHUKHRH1 | |
| SCHEMBL248096 | 0.76 | KDM4E (0.42) | NPC1KDM4EIKBKBTGFBR1MAPT | |
| SCHEMBL19331509 | 0.72 | NPC1 (0.40) | NPC1KDM4EHRH1TGFBR1RAB9A | |
| SCHEMBL16585320 | 0.71 | PIK3CD (0.47) | NPC1KDM4EHRH1MAPTTAAR1 | |
| SCHEMBL15320225 | 0.71 | PIK3CD (0.43) | NPC1KDM4EHRH1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL17241313 | 0.70 | PIK3CD (0.43) | NPC1KDM4EHRH1MAPTRAB9A | |
| SCHEMBL27928181 | 0.69 | HRH1 (0.48) | NPC1KDM4EHRH1RAB9ATAAR1 | |
| SCHEMBL4434943 | 0.68 | NPC1 (0.41) | NPC1KDM4ETGFBR1MAPTTAAR1 | |
| SCHEMBL7044148 | 0.64 | HRH1 (0.50) | NPC1KDM4EHRH1RAB9ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003262-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |