Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248097 | 0.80 | NPC1 (0.41) | ALDH1A1MAPTLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL252459 | 0.76 | IDO1 (0.38) | MAPTLMNASMN1; SMN2HPGDNPSR1 | |
| SCHEMBL246126 | 0.76 | IDO1 (0.38) | MAPTLMNASMN1; SMN2HPGDNPSR1 | |
| SCHEMBL16585132 | 0.76 | HSD17B10 (0.46) | HSD17B10PKMALDH1A1MAPTLMNA | |
| SCHEMBL15321315 | 0.76 | HSD17B10 (0.46) | HSD17B10PKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL248096 | 0.67 | KDM4E (0.42) | MAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL248919 | 0.67 | LMNA (0.42) | HSD17B10PKMALDH1A1MAPTLMNA | |
| SCHEMBL4437361 | 0.67 | ALDH1A1 (0.41) | PKMALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL23027794 | 0.66 | LMNA (0.65) | HSD17B10PKMALDH1A1MAPTLMNA | |
| SCHEMBL28261467 | 0.65 | HSD17B10 (0.55) | HSD17B10PKMALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003262-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |