Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dicyclomine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.90 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.90 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.90 |
| ▸ | LMNA | P02545 | 4/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.90 |
| ▸ | TSHR | P16473 | 4/20 | 0.90 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.90 |
| ▸ | DRD1 | P21728 | 2/20 | 0.90 |
| ▸ | DRD3 | P35462 | 2/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.90 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.90 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.90 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | HRH2 | P25021 | 1/20 | 0.90 |
| ▸ | HTR2A | P28223 | 1/20 | 0.90 |
| ▸ | HTR2C | P28335 | 1/20 | 0.90 |
| ▸ | HRH1 | P35367 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dicyclomine SCHEMBL8082728 | 0.99 | CYP3A4 (0.90) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL3317 | 0.95 | CYP3A4 (1.00) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL14322178 | 0.93 | CYP3A4 (0.97) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL41670 | 0.93 | CYP3A4 (1.00) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL10684080 | 0.93 | CYP3A4 (0.97) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL5501641 | 0.93 | CYP3A4 (1.00) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL20536388 | 0.93 | CYP3A4 (1.00) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL3051663 | 0.92 | CYP3A4 (0.95) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL7023518 | 0.92 | CYP3A4 (0.97) | CYP3A4CHRM2CHRM1LMNACYP1A2 | |
| Dicyclomine SCHEMBL6285092 | 0.91 | CYP3A4 (0.95) | CYP3A4CHRM2CHRM1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1978917-B1 | ANTIPERSPIRANT COMPOSITIONS | UNILEVER PLC (GB) | 2011-10-19 | — | — | EP | disclosed |
| EP-1978917-A1 | ANTIPERSPIRANT COMPOSITIONS | UNILEVER PLC (GB) | 2008-10-15 | — | — | EP | disclosed |
| US-20070178053-A1 | Antiperspirant compositions | CONOPCO INC, D/B/A UNILEVER | 2007-08-02 | — | — | US | disclosed |
| WO-2007085299-A1 | ANTIPERSPIRANT COMPOSITIONS | UNILEVER PLC (GB) | 2007-08-02 | — | — | WO | disclosed |