Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ASPH | Q12797 | 2/20 | 0.56 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.56 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.56 |
| ▸ | VNN1 | O95497 | 4/20 | 0.53 |
| ▸ | CD38 | P28907 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 5/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29976764 | 0.90 | KDM4E (0.56) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL24157190 | 0.90 | KDM4E (0.65) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL30253210 | 0.90 | KDM4E (0.65) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL21723070 | 0.90 | KDM4E (0.56) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL2479534 | 0.87 | AURKA (0.57) | KDM4EVNN1AURKARPS6KB1JAK3 | |
| SCHEMBL15270392 | 0.86 | GAA (0.56) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL22749399 | 0.86 | KDM4E (0.52) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL31252847 | 0.86 | GAA (0.56) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL2479053 | 0.86 | KDM4E (0.51) | KDM4EVNN1CD38JAK3JAK2 | |
| SCHEMBL2479527 | 0.86 | JAK3 (0.53) | KDM4EVNN1CD38RPS6KB1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575153-B2 | Pyridine-3-carboxyamide derivative | KOWA COMPANY, LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| US-8575153-B2 | Pyridine-3-carboxyamide derivative | KOWA COMPANY, LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| US-8575153-B2 | Pyridine-3-carboxyamide derivative | KOWA COMPANY, LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |
| CN-102227409-A | Pyridine-3-carboxyamide derivative | KOWA CO | 2011-10-26 | — | — | CN | disclosed |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | JAK3, JAK1, UACA | KDM4E 1516/4885ASPH 4597/4885KDM8 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.