Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 9/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.55 |
| ▸ | IGF1R | P08069 | 4/20 | 0.55 |
| ▸ | KIT | P10721 | 11/20 | 0.54 |
| ▸ | FLT3 | P36888 | 9/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1336409 | 0.97 | INSR (0.57) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL23901104 | 0.83 | ALK (0.56) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL1336480 | 0.82 | KIT (0.43) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL1334867 | 0.82 | INSR (0.80) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL3513707 | 0.82 | ALK (0.73) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL1334143 | 0.80 | INSR (0.72) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL30170755 | 0.80 | ALK (0.58) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL25396325 | 0.80 | ALK (0.58) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL28999470 | 0.80 | ALK (0.57) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL28999521 | 0.80 | ALK (0.62) | INSRALKIGF1RKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373626-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010069966-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-06-24 | — | — | WO | disclosed |