SCHEMBL24815841

SCHEMBL24815841

O=C(Nc1cccc(OC2CC(=C(F)F)C2)n1)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22122602 0.86 KIF18A (1.00) KIF18A
SCHEMBL24815845 0.84 KIF18A (0.83) KIF18A
SCHEMBL24815849 0.84 KIF18A (0.75) KIF18A
SCHEMBL25712777 0.84 KIF18A (0.84) KIF18A
SCHEMBL29609652 0.83 KIF18A (1.00) KIF18A
SCHEMBL22122452 0.83 KIF18A (1.00) KIF18A
SCHEMBL24319656 0.83 KIF18A (1.00) KIF18A
SCHEMBL29609732 0.83 KIF18A (1.00) KIF18A
SCHEMBL24319040 0.83 KIF18A (1.00) KIF18A
SCHEMBL29608037 0.83 KIF18A (1.00) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022268230-A1 COMPOUND AS KIF18A INHIBITOR 杭州英创医药科技有限公司 2022-12-29 — — WO disclosed
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