Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.61 |
| ▸ | INSR | P06213 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | NPM1 | P06748 | 4/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519996 | 0.84 | JAK2 (0.68) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519688 | 0.80 | JAK2 (0.68) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL16530534 | 0.80 | JAK2 (0.66) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519325 | 0.80 | JAK2 (0.65) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520579 | 0.80 | JAK2 (0.72) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL518831 | 0.79 | JAK2 (0.80) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520588 | 0.79 | JAK2 (0.71) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519188 | 0.79 | JAK2 (1.00) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519794 | 0.79 | JAK2 (0.83) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL2511251 | 0.79 | INSR (0.46) | JAK2ALKINSRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |