SCHEMBL24816992

SCHEMBL24816992

Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC(=C(F)F)CC2)nc(N2CCC(F)(F)CC2)c1

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24815679 0.94 KIF18A (0.83) KIF18A
SCHEMBL29608211 0.91 KIF18A (1.00) KIF18A
SCHEMBL22122482 0.91 KIF18A (1.00) KIF18A
Hydrochloric Acid SCHEMBL30141790 0.90 KIF18A (0.98) KIF18A
Hydrochloric Acid SCHEMBL23925817 0.90 KIF18A (0.98) KIF18A
SCHEMBL24815656 0.90 KIF18A (0.68) KIF18A
SCHEMBL24817162 0.90 KIF18A (0.85) KIF18A
SCHEMBL24816988 0.90 KIF18A (0.83) KIF18A
SCHEMBL24817159 0.89 KIF18A (0.84) KIF18A
SCHEMBL27376387 0.89 KIF18A (0.84) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022268230-A1 COMPOUND AS KIF18A INHIBITOR 杭州英创医药科技有限公司 2022-12-29 — — WO disclosed
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